Current developments in interventional treatment of total terminal aortic occlusions--laser, stenting and balloon angioplasty: experience of cardiology clinic of Targu-Mures.

Benedek I, Hintea T.
Clinic of Cardiology Emergency Clinical Hospital Mures Targu-Mures, Romania ibenedek@orizont.net

The importance of interventional procedures in the complex treatment of peripheral arterial diseases is continuously increasing. In the current practice of our clinic, association of balloon angioplasty, laser angioplasty and arterial stenting in reconstruction of iliac arteries led to superior results in the latest years, these methods 11:42 PM 11:42 PM 11:42 PM being proved as an alternative to surgical interventions. In this article, we present several cases in which current indications for laser angioplasty were extended to target occlusions located in the terminal abdominal aorta. METHODS: 106 consecutive primary iliac interventions were performed on 88 patients with iliac or aortoiliac obstructive diseases, in the period September 2001 - October 2005, at the University of Medicine and Pharmacy of Targu-Mures, Romania, Clinic of Cardiology. Five of these patients (4 males, 1 female) presented occlusions of terminal aorta, in whom interventional treatment (peripheral transluminal angioplasty, laser angioplasty and stenting) was performed. Three cases presented total occlusion of terminal aorta, without any visualization of iliac arteries, and 2 cases presented occlusion of one aortoiliac axis, starting from terminal aorta. RESULTS: In all cases, complete repermeabilisation of aortoiliac axes was achieved, without complications. In all patients we recorded a significant improvement of symptomatology, and arterial Doppler showed an increase of Doppler ankle/brachial index in average from 0.4 up to 0.95. No complications have been recorded so far. CONCLUSION: Extension of classical indications of interventional treatment for balloon and laser angioplasty to occlusions located in terminal aorta is possible when the procedure is performed by an experienced team. Interventional techniques, having a superior applicability in practice, good results, low complication rates, and decreasing the hospitalization times, could be applied in the future to a larger extent, targeting also aortic occlusions.

Chronic thromboembolic pulmonary hypertension - assessment by magnetic resonance imaging.

Kreitner KF, Kunz RP, Ley S, Oberholzer K, Neeb D, Gast KK, Heussel CP,
Eberle B, Mayer E, Kauczor HU, Duber C.
Department of Diagnostic and Interventional Radiology, Johannes-Gutenberg-University, Langenbeckstrasse 1, D-55131, Mainz, Germany, kreitner@radiologie.klinik.uni-mainz.de.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe disease that has been ignored for a long time. However, with the development of improved therapeutic modalities, cardiologists and thoracic surgeons have shown increasing interest in the diagnostic work-up of this entity. The diagnosis and management of chronic thromboembolic pulmonary hypertension require a multidisciplinary approach involving the specialties of pulmonary medicine, cardiology, radiology, anesthesiology and thoracic surgery. With this approach, pulmonary endarterectomy (PEA) can be performed with an acceptable mortality rate. This review article describes the developments in magnetic resonance (MR) imaging techniques for the diagnosis of chronic thromboembolic pulmonary hypertension. Techniques include contrast-enhanced MR angiography (ce-MRA), MR perfusion imaging, phase-contrast imaging of the great vessels, cine imaging of the heart and combined perfusion-ventilation MR imaging with hyperpolarized noble gases. It is anticipated that MR imaging will play a central role in the initial diagnosis and follow-up of patients with CTEPH.

Percutaneous coronary intervention for chronic total occlusion in 1263 patients: a single-center report.

Han YL, Wang SL, Jing QM, Li Y, Zhang J, Ma YY, Luan B.
Department of Cardiology, Shenyang General Hospital of PLA, Shenyang 110016, China hanyal@mail.sy.ln.cn

BACKGROUND: Coronary chronic total occlusion (CTO) remains one of the most challenging lesion subsets in interventional cardiology, even with the development of medical device and operator expertise. This study was conducted to examine the relationship between lesion characteristics and procedural success and the incidence of in-hospital major adverse cardiac events (MACE) after percutaneous coronary intervention (PCI) for CTO. METHODS: Clinical and coronary angiographic data of 1263 patients with CTO who underwent PCI between June 1995 and December 2005 in Shenyang General Hospital of PLA were retrospectively analyzed. RESULTS: There were 1625 CTO lesions located in 1596 vessels with a mean occlusion time of 48.9 months. A total of 1647 coronary stents were implanted to the target lesions. The overall patient and lesion success rates were 90.8% (1147/1263) and 88.9% (1445/1625), respectively. The success rate of PCI was declined with long duration of occlusion, abrupt missing stump, bridging collaterals > or = 15 mm in occluded length, moderate to severe calcification or tortuosity and ostial or distal location of CTO lesions (P < 0.05). Procedural failure occurred in 116 patients, caused by impossibility of guide-wire (81.0%) or balloon (19.0%) to pass through the occlusion. There was no death during procedure, but 2 patients suffered from acute stent thrombosis and other 9 patients had acute or late pericardial perforation. Those complications were all successfully treated. After procedure, 3 patients died, 4 experienced urgent target vessel revascularization because of subacute stent thrombosis and 1 underwent coronary bypass graft surgery due to coronary fistula during in-hospital period. The overall in-hospital MACE rate was 0.6% (8/1263). Drug-eluting stents were used in 198 patients without in-hospital MACE. CONCLUSIONS: In an experienced heart center, it is possible to obtain a relatively high success rate of PCI and favorable clinical outcomes for patients with coronary CTO lesions.